Restless Legs Syndrome (RLS): Diagnosis
There is no laboratory test to confirm a diagnosis of RLS. However, a thorough examination followed by laboratory tests, can reveal temporary disorders, such as iron deficiency, that may be associated with RLS.

If a patient's description of symptoms and history suggests RLS, blood tests may be performed to rule out conditions like anemia, decreased iron stores, diabetes, and renal dysfunction. Electromyography (EMG) and nerve conduction studies may also be recommended to measure electrical activity in muscles and nerves. Likewise, Doppler sonography may be used to evaluate muscle activity in the legs. Negative results from these tests may indicate RLS.