Carpal Tunnel Syndrome: Symptoms
The primary symptoms of carpal tunnel syndrome are pain and numbness in the thumb, index, and middle fingers that often worsen at night and may radiate to the upper arm. Symptoms usually occur near the palm of the hand. Other symptoms include muscle weakness in the hand and wrist, tingling, and impaired reflexes.

 In advanced cases of carpal tunnel syndrome, shrinkage or atrophy of the fleshy area at the base of the thumb may occur.